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Permeability Of Hydrophilic
Part 1 of Paper
....e in this report. The cell line was isolated from rat fetal
intestinal epithelial cells and transfected with thermolabile SV40 large T
antigen.
These cells proliferated at 33 °C, but eliminated the antigen and ceased
proliferating at a non-permissive temperature (39°C). At 39°C 2/4/A1 cells
started to differentiate.... Part 2 of Paper
....-2 cells.
These results indicated that 2/4/A1 cells could be used as a model for
hydrophilic drug absorption.
INTRODUCTION
The small intestine plays a crucial role in the absorption of drugs and
nutrients. Exogenous substances cross a series of barriers during the process
of intestinal absorption: (1) the aqueous boundary/mucus layer, (2) a single
layer of epithelial cells, and (3) the lamina propria, which contains the blood
and lymph vessels that then transport the absorbed drugs to other .... |
| Number of words: 2422 - Approximate pages: 9 |
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